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Payphone! PDF Print E-mail
Written by Administrator   
Friday, 18 December 2009 01:39

This is one of the best gifts I've ever received (back in 2007)... a used public payphone. It's an Intellicall UltraTel, made sometime in the mid 1990s. These older Ultratel payphones are AC powered instead of phone-line powered like most modern payphones. Even the older Western Electric payphones made by Ma Bell were line powered, so this phone is unique in that respect. Unfortunately, when the unit was taken out of service, the power cable was cut, leaving the AC transformer somewhere in the 970 area code.

I had to order a new AC transformer, handset cradle, and battery and eventually got the phone powered up and got a dial tone. Then I had to have Intellicall program it remotely, and now it now makes and receives calls. It's an interesting phone... every time we get a call, the phone's coin mechanism clicks to release any coins if there happened to be any in there. The phone also dials 111 every time we answer a call on it. Unfortunately I had to disconnect the phone line from it because my daughter learned to walk... and she learned to press buttons and take the handset off its cradle. Now all she hears is a tinny female voice saying "Please hang up and try again". As my daughter gets older, I'll be able to connect the phone again and use it as a regular phone. I also think as she gets older, this will be one of the only payphones she'll ever see and use.

Last Updated on Tuesday, 29 December 2009 17:58
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Ebony dominoes PDF Print E-mail
Written by Administrator   
Tuesday, 15 December 2009 21:24

For Rachel's 3rd Hanukkah, I decided to make wooden dominoes. I chose Gabon ebony for the dominoes and rosewood for the box to hold them. Working with Tropical hardwoods was quite an experience because they are so much denser than any North American hardwood. Tropical woods hold an edge much better than cherry or maple, and combined with its near black color, made it perfect for small dominoes.

Last Updated on Tuesday, 29 December 2009 18:03
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Publications PDF Print E-mail
Written by Administrator   
Wednesday, 09 December 2009 02:18

Publications

Tolin, D. F., Kiehl, K. A., Worhunsky, P., Book, G. A., & Maltby, N. (2009). An exploratory study of the neural mechanisms of decision-making in compulsive hoarding. Psychological Medicine, 38, 1-12. [PDF]

G.A.Book, Q. Wang, S. Ortiz, C. Primiano, R. McKay, W. Sun, Dimensional Analysis of Aortic Valve Geometry from Clinical 64-Slice MSCT Scans: A Comparison of Methods, Submitted to The American Journal of Cardiology, 2010

Awards

fMRI of Brain Activation During Menstrual Migraine - Departmental award from Olin Center, July 2006 ($8,955)

 

Posters/Conference Abstracts

G.A. Book, M.C. Stevens, G. Pearlson, K.A. Kiehl - Fusion of fMRI and the Pupil Response During an Auditory Oddball Task - Accepted to the 2008 Conference of the Cognitive Neuroscience Society [Abstract] [Poster]

L. Miller, M. Assaf, G.A. Book, G.D. Pearlson - Face Building: An fMRI investigation of brain activation of faces versus houses, objects, and patterns in individuals with high functioning autism. - Accepted to the 2008 Conference of the Cognitive Neuroscience Society

G.A. Book, A.D. Thomas, M.R. Johnson, J.L. Hylton, M.M. Andrews, M. Assaf, G.D. Pearlson. - Reward Processing in Social Competitive Task in Subjects with Familial History of Alcoholism - International Conference on Applications of Neuroimaging to Alcoholism January 2008 [Abstract] [Poster]

A.L. Byrd, M.S. Shane, G.A. Book, E. Mulder, R.E. Kahn, O. Antonenko, K.A. Kiehl - Response Inhibition as a Protective Factor against Incarceration in Those High and Low in Psychopathic Traits - Conference of the Society for the Scientific Study of Psychopathy April 2007

M.M. Andrews, S.A. Meda, G.A. Book, J.L. Hylton, A.D. Thomas, M Potenza, P Worhunsky, M.C. Stevens G.D. Pearlson - Differences In Reward Circuit Activation In People With a Family History Of Alcoholism - International Conference on Applications of Neuroimaging to Alcoholism January 2008

 

Presentations

Gregory A Book - Introduction to Perl Programming - Presented at Olin Center, August 2006 [PDF]

Gregory A Book - Migraine Pathogenesis - Presented at Olin Data Talks September 25, 2007 [PDF]

Nicholas Maltby, Patrick Worhunsky, Gregory A. Book, Kent A. Kiehl, David F. Tolin - Putting Neurobiological Models of OCD to the Test, An fMRI Study of Specifity and Response to Treatment

Last Updated on Sunday, 24 October 2010 14:33
 
fMRI of Menstrual Migraine PDF Print E-mail
Written by Administrator   
Tuesday, 08 December 2009 03:22

This was a fascinating project that I worked on at the Olin Center from 2006 to 2008. My goal with this project was to induce a migraine in participants while they received a functional MRI scan. The goal from that is to observe migraine pathogenesis, or any interesting physiologic activity that occurs at the beginning of migraine. The biggest challenge was actually getting someone to get a migraine while the scanner was running. I had a self imposed time limit of about an hour for the participant to be in the scanner, because of expensive scan slots, scanner scheduling, and that no one with a migraine would want to be scanned for that long.

It took a lot of work to get the IRB to approve the protocol, but because I was going to scan menstrual associated migraines, the IRB eventually got the picture. Women with menstrual associated migraines get migraines like clockwork at the beginning of their menstruation cycle, so they would get a migraine whether we scanned them or not. It just happened to the best time to scan them. When I told a friend what I was doing in this project, he said "You have the greatest job in the world. You're going to find PMSing women, give them a migraine and then give them an MRI. Good luck". It actually turned out to be pretty difficult to induce a migraine, even in women with predictable menstrual migraine.

My initial recruitment goal was 15 subjects (6 migraine w/aura, 6 migraine w/out aura, 3 healthy controls). As of Fall 2007 I had recruited 12, scanned 7 (including test subjects to tweak protocol), and successfully induced and observed a migraine in one patient. I gave a talk at the Olin Neuropsychiatry Research Center on September 25, 2007 about the study and a summary of current migraine pathogenesis understanding. The talk is available in PDF. The most interesting finding for the single subject who got a migraine was a negative activation in the trigeminal ganglion during the visual stimulation from the flashing checkerboards. The subject who did not get a migraine had no activation there. The MR angiogram produced no significant changes in blood vessel diameter.

 
MRI data storage system PDF Print E-mail
Written by Administrator   
Wednesday, 09 December 2009 02:41

The Olin Center was started back in 2003, with it's first recorded scans in April. The archiving and retrieval method at the time was a simple web interface that had access to only the past 30 days worth of data. The rest of the data was archived to DVD. After a couple years it became tough to find the data you wanted because you'd need to sift through 200 DVDs to find the MRI scans you wanted. It became more challenging if you needed data from 100 subjects. So in 2005 I built 4 servers to house the MRI data and created a simple web interface to allow people to search and download the directly to our analysis servers. The whole system was dubbed "All Data Online" or the adoserver for short.

In 2007 I rebuilt the system, distributing the data between 2 servers. At the time, there was approximately 6.5TB of data stored on the servers, all instantly searchable and downloadable. Earlier this year, I needed to rebuild the system and placed the entire system on a single server... The trend from 4 to 2 to 1 server is because of the tremendous drop in the price of disk space. It's just more affordable to have 14TB of space on a single server than 2 servers with 7TB. It's also easier to maintain. Since the amount of data transfer on and off the server is about 8GB/day, there's no bottleneck in keeping it in one place.

Now, at the end of 2009 after 7 years of collecting MRI data, our data is archived in triplicate on 1200 DVDs, we have more than 7500 MRI studies, and 170,000 series of MRI data, stored in 4 different formats. In total there are 12TB of data in approximately 68 million files, and the system has used 160 CPU-days to process and archive the data. There are also new reporting, auditing, and trend monitoring tools. Searches are faster and more comprehensive, with thumbnail image results. There have been approximately 40,000 data requests since the system was created, though the counter was reset with each new system.

 

Last Updated on Tuesday, 29 December 2009 19:45
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